Manganese(II)‐Guided Separation in the Sub‐Nanometer Regime for Precise Identification of In Vivo Size Dependence

• DOI: 10.1002/anie.202214720
• Publication Date: 2023-01-18T16:04:17Z
• Authors: Wei Cai; Yue Tan; Kui He; Bing Tang; Jinbin Liu
• Keywords: Nanometre; Nanotoxicology

A precise understanding of nano-bio interactions in the sub-nanometer regime is necessary for advancements nanomedicine. However, this currently hindered by control nanoparticle size regime. Herein, we report a facile situ Mn2+ -guided centrifugation strategy synthesis large-scale ultrasmall gold nanoparticles (AuNPs) with precisely controlled gradient at With discovery that [Mn(OH)]+ , especially metallic manganese (Mn0 @[Mn(OH)]+ ) nanoparticles, could selectively interact larger AuNPs through synergistic coordination and hydrogen bonding to form aggregates, also realized fast (<1 h) water-soluble atomically Au25 high yields (>56 %). We further demonstrated differences (approximately 0.5 nm) significantly alter non-specific phagocytosis reticuloendothelial system macrophages, elimination rate, nanotoxicology.