Photocatalytic Alkylation of C(sp3)−H Bonds Using Sulfonylhydrazones**

• DOI: 10.1002/anie.202215374
• Publication Date: 2022-11-17T11:46:56Z
• Authors: Antonio Pulcinella; Stefano Bonciolini; Florian Lukas; Andrea Sorato; Timothy Noël
• Keywords: Sulfonyl

The ability to construct C(sp3 )-C(sp3 ) bonds from easily accessible reagents is a crucial, yet challenging endeavor for synthetic organic chemists. Herein, we report the realization of such cross-coupling reaction, which combines N-sulfonyl hydrazones and )-H donors through diarylketone-enabled photocatalytic hydrogen atom transfer subsequent fragmentation obtained alkylated hydrazide. This mild metal-free protocol was employed prepare wide array alkyl-alkyl cross-coupled products tolerant variety functional groups. application this chemistry further provides preparatively useful route various medicinally-relevant compounds, as homobenzylic ethers, aryl ethyl amines, β-amino acids other moieties are commonly encountered in approved pharmaceuticals, agrochemicals natural products.