Enzymatic Synthesis of Noncanonical α‐Amino Acids Containing γ‐Tertiary Alcohols

• DOI: 10.1002/anie.202318550
• Publication Date: 2023-12-29T03:16:21Z
• Authors: Rui Zhang; Chenghua Zhang; Jiamu Tan; Yifan He; Dan Zhuo; Jingxuan Zhang; Zhenzhen Luo; Qiaoqiao Li; Jiaying Yao; Changqiang Ke; Chunping Tang; Yang Ye; Shijun He; Xiang Sheng; Cangsong Liao
• Keywords: Stereocenter; Aldol reaction; Biocatalysis

Noncanonical amino acids (ncAAs) containing tertiary alcohols are valuable as precursors of natural products and active pharmaceutical ingredients. However, the assembly such ncAA scaffolds from simple material by C-C bond formation remains a challenging task due to presence multiple stereocenters large steric hindrance. In this study, we present novel solution problem through highly selective enzymatic decarboxylative aldol addition. This method allows for streamlined multifunctionalized ncAAs with γ-tertiary readily available materials,