Tensile Strain‐Mediated Bimetallene Nanozyme for Enhanced Photothermal Tumor Catalytic Therapy

• DOI: 10.1002/anie.202403203
• Publication Date: 2024-04-09T07:42:30Z
• Authors: Jiandong Wu; Qihui Liu; Dongxu Jiao; Bin Tian; Qiong Wu; Xin Chang; Hongyu Chu; Shan Jiang; Qi Yang; Tao Liu; Yue Zhang; Wei Zhang; Jinchang Fan; Xiaoqiang Cui; Fangfang Chen
• Keywords: Strain (injury); Strain engineering; Tensile strain

Abstract Nanozymes have demonstrated significant potential in combating malignant tumor proliferation through catalytic therapy. However, the therapeutic effect is often limited by insufficient performance. In this study, we propose utilization of strain engineering metallenes to fully expose active regions due their ultrathin nature. Here, present first report on a novel tensile strain‐mediated local amorphous RhRu (la‐RhRu) bimetallene with exceptional intrinsic photothermal and photo‐enhanced multiple enzyme‐like activities. Through geometric phase analysis, electron diffraction profile, X‐ray diffraction, it revealed that crystalline‐amorphous heterophase boundaries can generate approximately 2 % bimetallene. The structure in‐plane induce an amplified effect. Both experimental theoretical evidence support notion promotes Functioning as microenvironment (TME)‐responsive nanozyme, la‐RhRu exhibits remarkable efficacy both vitro vivo. This work highlights tremendous atomic‐scale strategy enhancing