Enantioselective copper(II)‐catalyzed Henry reaction utilizing chiral aziridinyl alcohols

• DOI: 10.1002/aoc.3232
• Publication Date: 2014-10-27T10:30:07Z
• Authors: Xiaojuan Wang; Wenxian Zhao; Gaowei Li; Jin Wang; Guanjun Liu; Lantao Liu; Ruijuan Zhao; Mincan Wang
• Keywords: 01 natural sciences; 0104 chemical sciences

A family of enantiopure β‐aminoalcohols based on aziridine backbones were synthesized, and examined as chiral ligands for the copper(II)‐catalyzed asymmetric Henry reaction of aromatic aldehydes with nitromethane, giving β‐nitroalcohols in excellent yields (up to 93%) and moderate to good enantioselectivities (up to 82%). Moreover, possible transition states of the reaction are proposed. Copyright © 2014 John Wiley & Sons, Ltd.