Antioxidative vs cytotoxic activities of organotin complexes bearing 2,6‐di‐tert‐butylphenol moieties

• DOI: 10.1002/aoc.4381
• Publication Date: 2018-04-17T18:10:03Z
• Authors: T.A. Antonenko; D.B. Shpakovsky; M.A. Vorobyov; Yu.A. Gracheva; E.V. Kharitonashvili; L.G. Dubova; E.F. Shevtsova; V.A. Tafeenko; L.A. Aslanov; A.G. Iksanova; Yu.G. Shtyrlin; E.R. Milaeva
• Keywords: Octahedral molecular geometry; Tetrahedral molecular geometry; Base (topology)

Two series of organotin(IV) complexes with Sn–S bonds on the base 2,6‐di‐ tert ‐butyl‐4‐mercaptophenol ( L 1 SH ) formulae Me 2 Sn(L S) ); Et Bu 3 Ph 4 (L 5 6 7 = 3,5‐di‐ ‐butyl‐4‐hydroxyphenyl), together new ones [Me SnCl(L )] 8 ), SnCl ] 9 2‐(N‐3 ′ ,5 ‐di‐ ‐butyl‐4 ‐hydroxyphenyl)‐iminomethylphenol) were used to study their antioxidant and cytotoxic activity. Novel , n − 3, 2) Schiff synthesized characterized by H, 13 C NMR, IR elemental analysis. The crystal structures compounds determined X‐ray diffraction distorted tetrahedral geometry around Sn center in monocrystals was revealed, is coordinated tin(IV) atom electrostatic interaction formation short contact Sn–O 2.805 Å. In case complex octahedron coordination formed. activity as radical scavengers reducing agents proved spectrophotometrically tests stable DPPH, reduction Cu 2+ (CUPRAC method) superoxide radical‐anion. Moreover, have been screened for vitro cytotoxicity eight human cancer cell lines. A high against all lines IC 50 values 60–160 nM triphenyltin while introduction decreased complexes. influence mitochondrial potential permeability has studied. It shown that studied depolarize mitochondria but don't calcium‐induced transition.