Synthesis, characterization, crystal structure of novel Cu (II), Co (III), Fe (III) and Cr (III) complexes with 2‐hydroxybenzaldehyde‐4‐allyl‐S‐methylisothiosemicarbazone: Antimicrobial, antioxidant and in vitro antiproliferative activity

• DOI: 10.1002/aoc.4544
• Publication Date: 2018-10-09T13:10:42Z
• Authors: Elena Pahontu; Irina Usataia; Vasilii Graur; Yurii Chumakov; Peter Petrenko; Valentin Gudumac; Aurelian Gulea
• Keywords: HeLa; Octahedral molecular geometry; Molar conductivity

2‐Hydroxybenzaldehyde‐4‐allyl‐S‐methylisothiosemicarbazone and Cu (II), Co (III), Fe (III) Cr complexes were synthesized characterized. The new obtained compounds investigated by elemental analysis, magnetic susceptibility measurements, molar electric conductivity, IR, 1 H NMR, 13 C UV–Vis spectroscopy. In addition, the structure of ligand six has been determined single‐crystal X‐ray diffraction analysis. atom in complex 3 is penta‐coordinated a distorted square–pyramidal coordination geometry, while metals 5 – 9 are octahedral environment. For all antimicrobial activity was studied on series standard strains, such as Staphylococcus aureus , Escherichia coli Enterococcus faecalis Salmonella abony Candida albicans . vitro antiproliferative screened human leukemia HL‐60 cells, cervical epithelial HeLa pancreatic adenocarcinoma BxPC‐3 muscle rhabdomyosarcoma spindle large multinucleated RD cells. primary screening wider cancer cells showed that copper compound 2 manifests high towards HeLa, which three–six times higher than doxorubicin. selectivity index ratio between IC 50 value for normal MDCK values varies range 2.44–21.17. This 5.5–11 6–9 manifest antioxidant ABTS •+ exceeds 47–67 Trolox.