Silica‐supported Cu(II)–quinoline complex: Efficient and recyclable nanocatalyst for one‐pot synthesis of benzimidazolquinoline derivatives and 2H‐indazoles

• DOI: 10.1002/aoc.4974
• Publication Date: 2019-05-22T03:24:15Z
• Authors: Hashem Sharghi; Mahdi Aberi; Pezhman Shiri
• Keywords: 01 natural sciences; 12. Responsible consumption; 0104 chemical sciences

The synthesis, characterization and catalytic activity of a Cu(II) complex derived from 2‐oxoquinoline‐3‐carbaldehyde Schiff base supported on amino‐functionalized silica are reported. 3‐(1H‐Benzo[d]imidazol‐2‐yl)quinolines containing piperidine, morpholine and phenylpiperazine skeletons at the C‐2 position were formed in good to excellent yields via the one‐pot reaction of 2‐chloroquinoline‐3‐carbaldehyde, benzene‐1,2‐diamines and secondary amines in the presence of the nanocatalyst under mild conditions. Moreover, the nanocatalyst was found to be recyclable for up to seven runs without significant loss of activity. Also, a series of 2H‐indazoles were synthesized by the catalytic condensation of 2‐bromobenzaldehyde, sodium azide and primary amines.