Aminohalogenation of maleimides with alkylamines and XCH2CH2X (X = Cl, Br)

• DOI: 10.1002/aoc.7046
• Publication Date: 2023-02-07T05:57:04Z
• Authors: Jingjing Wang; Yaling Xu; Luya Chen; Yunfei Ma; Ge Wu
• Keywords: 01 natural sciences; 0104 chemical sciences

The nucleophilic substitution of organohalides with alkylamines is one the most heralded reactions in synthetic chemistry. However, resulting halide anions are often wasted routine workup experiments and not fully utilized. Herein, we report a halogen recycling strategy for radical aminohalogenation maleimides XCH 2 CH X (X = Cl, Br) excellent functional group compatibility. strategy's generality demonstrated by 38 aminohalogenated products, twofold aminochlorination, late‐stage vinylchlorination nortriptyline.