Structure, interaction with biomolecules, and cytotoxicity of copper (II) complexes chelating some Schiff base ligands

• DOI: 10.1002/aoc.7253
• Publication Date: 2023-09-11T23:13:36Z
• Authors: Aleksandar Mijatović; Angelina Z. Caković; Aleksandar Lolić; Olivera Klisurić; Marko N. Živanović; Dragana S. Šeklić; Snežana Sretenović; Marija Ilić; Jovana Bogojeski
• Keywords: Bovine serum albumin; Moiety; Piperazine

Cancer remains one of the most common diseases worldwide in terms deaths and claims many lives every day. Transition metal complexes are candidates development anticancer drugs, with cisplatin being used chemotherapy worldwide. Copper, an endogenous metal, is known for its pronounced redox potential nucleophilicity, especially when bound to biological molecules. Cu (II) were synthesized containing ethane‐1,2‐diamine as amine moiety pentane‐2,4‐dione and/or 1‐phenylbutane‐1,3‐dione, 1,1,1‐trifluoropentane‐2,4‐dione or 1‐phenylbutane‐1,3‐dione β‐diketone moiety. Standard methods confirm structure 1–6 . X‐ray crystal analysis characterized complex 1 ligand pentane‐2,4‐dione. The interactions – 6 calf thymus DNA (ct‐DNA) followed by electronic absorption fluorescence spectroscopy viscosity measurements. In contrast, interaction Salmon Sperm was investigated using electrophoretic mobility shift assay. results indicate a moderate affinity binding DNA. Gel electrophoresis also shows that studied have concentration‐dependent Spectroscopic techniques monitor bovine serum albumin (BSA). Complexes showed satisfactory ability BSA. Cytotoxicity analyses performed on human colorectal carcinoma HCT‐116 healthy lung fibroblast MRC‐5 cell lines, showing 5 exhibited selectivity between cancer normal cells, which critical drug development.