Heterometallic bridged Pt(II)‐Zn(II) complexes: Influence of the substituent in 4′‐position in inert terpy ligand on antigenotoxicity, potential antitumor activity and mechanism of interactions of the complexes with biomolecules

• DOI: 10.1002/aoc.7413
• Publication Date: 2024-02-21T05:55:50Z
• Authors: Majda Kolenović S...; Rušid Hasić; Darko Ašanin; Biljana Šmit; Sanja Lj. Matić; Marina Ćendić Ser...; Danijela Nikodijević; Jovana Jovankić; Sanja Grgurić‐Šipka; Tanja V. Soldatović
• Keywords: Terpyridine; Pyrazine; Bioinorganic chemistry

The synthesis and characterization of novel hetrometallic complexes [{ cis ‐PtCl(NH 3 ) 2 ( μ ‐4,4′‐bipyridyl)ZnCl(terpy‐Cl)}](ClO 4 C1a ), trans ‐4,4′‐bipyridyl)ZnCl(terpy)}](ClO C2a ‐pyrazine)ZnCl(terpy‐Cl)}](ClO C3a C4a (where terpy‐Cl = 4′‐chloro‐2,2′:6′,2′′‐terpyridine) was done. Acid–base titrations were performed by UV–Vis spectrophotometric method to evaluate the p K a values corresponding aqua complexes. Interactions between important biomolecules, guanosine‐5′‐monophosphate (5′‐GMP) glutathione (GSH) examined 1 H NMR spectroscopy. chloride substituent at 4′ position on middle pyridine ring terpyridine ligand significantly affects coordination as well overall stability evaluated in vitro for antioxidant prevention DNA damages. All tested demonstrated significant reduction damage against oxidative modifications caused hydroxyl peroxyl radicals. Also, cytotoxicity evaluation showed that occurs only after long‐term effect , HCT‐116 cells. Molecular docking studies predict results agreement with experimental research.