Synthesis, characterization, DNA interaction, molecular docking, and α‐glucosidase inhibition studies of 3‐(pyrimidin‐2‐ylthio) groups substituted water soluble zinc (II) phthalocyanine

• DOI: 10.1002/aoc.7583
• Publication Date: 2024-06-17T08:08:56Z
• Authors: Nagihan Saglam Er...; Ece Tugba Saka; Tugba Taskin‐Tok; Melike Yildirim A...; Kadriye Inan Bektas; Ahmet Colak
• Keywords: Water soluble; Molecular model; Docking (animal)

In this work, 3‐(pyrimidin‐2‐ylthio)phthalonitrile (n‐MP1), non‐peripherally 3‐(pyrimidin‐2‐ylthio) groups substituted Zn (II) phthalocyanine (n‐MP2), and its water soluble derivative (n‐MP3) have been firstly synthesized characterized with spectral data. The interaction of the n‐MP3 complex DNA was examined in vitro using UV–visible titrimetric thermal denaturation assays silico by performing molecular docking studies. addition, antidiabetic activity revealed spectroscopically studying α‐glucosidase inhibition activities. spectroscopic results indicated that effectively binds to CT‐DNA a K b value 2.0 × 10 5 M −1 interacts via noncovalent binding mode. Besides, studies divulged exhibits stronger tendency (BE: −10.64 kcal/mol) than control compounds, (7.78 kcal/mol for ethidium bromide −6.21 cisplatin). Consequently, due strong activity, may be suitable antimicrobial anticancer applications after further toxicological test systems. Also, inhibited IC 50 1.44 ± 0.08 μM, whereas acarbose 237.24 1.80 μM. Therefore, it can said is very effective inhibitor.