Fabrication and characterization of poly(vinyl alcohol)/graphene oxide nanofibrous biocomposite scaffolds

• DOI: 10.1002/app.37924
• Publication Date: 2012-05-09T16:21:21Z
• Authors: Y. Y. Qi; Z. X. Tai; D. F. Sun; J. T. Chen; H. B. Ma; X. B. Yan; B. Liu; Q. J. Xue
• Keywords: Vinyl alcohol; Electrospinning; Biocomposite; Polyvinyl Alcohol; Thermogravimetric analysis

Abstract Nanofibrous biocomposite scaffolds of poly(vinyl alcohol) (PVA) and graphene oxide (GO) were prepared by using electrospinning method. The microstructure, crystallinity, morphology the characterized through X‐ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM). mechanical properties investigated tensile testing. Moreover, Mouse Osteoblastic Cells (MC3T3‐E1) attachment proliferation on nanofibrous MTT [3‐(4,5‐dimeth‐ylthiazol‐2‐yl)‐2,5‐diphenyl tetrazolium bromide] assay, SEM observation fluorescence staining. XRD FTIR results verify presence GO in scaffolds. images show three‐dimensional porous fibrous morphology, average diameter composite fibers decreases with increasing content GO. are altered changing as well. strength elasticity modulus increase when is lower than 1 wt %, but decrease up to 3 5 %. MC3T3‐E1 cells attach grow surfaces scaffolds, adding do not affect cells' viability. Also, likely spread PVA/GO Above all, these unique features would open a wide variety future applications bone tissue engineering drug delivery systems. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013