Electro‐conductive nanofibrous structure based on PGS/PCL coated with PPy by in situ chemical polymerization applicable as cardiac patch: Fabrication and optimization

• DOI: 10.1002/app.52136
• Publication Date: 2022-01-10T13:46:25Z
• Authors: Aref Fakhrali; Dariush Semnani; Hossein Salehi; Mohammad Ghane
• Keywords: Biocompatibility; Electrospinning; Polypyrrole

Abstract As a special structure and due to the unique properties of submicron‐scale fibers electrical conductivity, conductive nanofibers recently attracted further attention in various fields, especially tissue engineering. This study aimed coat poly (glycerol sebacate) (PGS) nanofiber/poly(caprolactone) (PCL) as widely used combination fields medicine with poly(pyrrole) (PPy) polymer, subsequently studying optimizing production process variables using response surface methodology (RSM). The samples were examined for morphological structural, their conductivity electroactivity measured four‐point probe system cyclic voltammetry, respectively. electrospinning conditions constructing substrate smallest diameter optimized. monomer concentration 0.05M polymerization time 3.3 h exploiting RSM also considered optimal obtaining coated‐nanofibers desired (0.001 S/cm). structural findings confirmed successful synthesis PGS PPy. conductive‐nanofiber produced under revealed good mechanical (tensile strength = 3.12 ± 0.19 MPa elongation at break 80.26 13.71%). highest biocompatibility was observed sample synthesized pyrrole 0.05M, which can be suitable candidate application cardiac