Synthesis and Anticonvulsant Activity of NewN‐(Alkyl/Sub‐stituted aryl)‐N′‐[4‐(5‐cyclohexylamino)‐1,3,4‐thiadiazole‐2‐yl)phenyl]thioureas

• DOI: 10.1002/ardp.200800118
• Publication Date: 2008-11-26T07:15:26Z
• Authors: Sevgi Karakus; Bedia Koçyığıt‐Ka...; Hale Z. Toklu; Feyza Aricioglu; Sevim Rollas
• Keywords: Moiety; Proton NMR

A series of novel thiourea derivatives carrying the 5-cylohexylamino-1,3,4-thiadiazole moiety was synthesized and their anticonvulsant activity evaluated. Structures compounds have been confirmed by IR, 1H-NMR, elemental analysis. All were administered at a dose 50 mg/kg. Some active different effects in pentylenetetrazole (PTZ) maximal electroshock (MES) tests, indicating therapeutical potential petit mal seizures, but not grand seizures. Compounds 10, 11, 13, 14 2-methylphenyl, 4-chlorophenyl, allyl, 4-methylphenyl on pharmacophore, increased survival rate PTZ model. The ED50 values found 68.42, 43.75, 18.75 25 mg/kg, respectively.