Synthesis of novel benzylamine antimycotics and evaluation of their antimycotic potency

• DOI: 10.1002/ardp.202300381
• Publication Date: 2024-02-12T13:06:53Z
• Authors: Monika Klimt; Martina Stadler; Ulrike Binder; Jürgen Krauss
• Keywords: Yarrowia; Benzylamine; Reductive amination; Side chain; Candida parapsilosis; Tertiary amine

Abstract A series of 23 novel benzylamines was synthesized by reductive amination from halogen‐substituted 3‐ and 4‐benzyloxybenzaldehyde derivatives 6‐methylhept‐2‐yl amine or n ‐octylamine. The antimycotic activity the resulting amines evaluated in a microdilution assay against apathogenic yeast Yarrowia lipolytica as test microorganism. Promising compounds were also tested human pathogenic Candida species. influence halogen substituents at benzyl ether side chain studied this screening, well branched (±)‐6‐methylhept‐2‐yl comparison with ‐octyl chain.