A computational model for single cell Lamin‐A structural organization after microfluidic compression

• DOI: 10.1002/bit.28810
• Publication Date: 2024-07-18T04:44:07Z
• Authors: Maria Isabella Ma...; Filippo Causa
• Keywords: mechanobiology; Nuclear lamina

In recent years, nuclear mechanobiology gained a lot of attention for the study cell responses to external cues like adhesive forces, applied compression, and/or shear-stresses. details, Lamin-A protein-as major constituent nucleus structure-plays crucial role in overall mechanobiological response. However, modeling and analysis protein organization upon rapid compression conditions microfluidics are still difficult be performed. Here, we introduce possibility control an microfluidic on single cells, deforming them up level. wide range stresses (~1-10