Dangerous halo after neoadjuvant chemotherapy and two-step hepatectomy for colorectal liver metastases

• DOI: 10.1002/bjs.6436
• Publication Date: 2008-12-24T09:44:26Z
• Authors: G Mentha; S Terraz; P Morel; A Andres; E Giostra; A Roth; L Rubbia-Brandt; P Majno
• Keywords: Neoadjuvant Therapy

Bilobar colorectal metastases are a therapeutic challenge and require multidisciplinary approach. The aim of this study was to describe the clinical histological outcomes patients having neoadjuvant chemotherapy two-step hepatectomy with right portal vein occlusion for advanced bilateral metastases.A series 23 consecutive treated curative intent according standardized management protocol reviewed.Of patients, 22 completed programme. There no mortality Clavien grade III morbidity. Median survival from start treatment 45 months, 1-, 3- 5-year Kaplan-Meier estimates were 95, 73 27 per cent respectively. On histology at first operation, ten had dangerous halo proliferating tumour cells infiltrating surrounding liver parenchyma, variable importance (six focal four diffuse), regardless response metastases. increased in prevalence seven diffuse) between second operation.Neoadjuvant followed by is feasible, safe may be advantageous patient. appearance around adaptation surgical technique decrease risk local recurrence.