Prognostic impact of lymph node metastasis in distal cholangiocarcinoma

• DOI: 10.1002/bjs.9752
• Publication Date: 2015-01-22T11:53:24Z
• Authors: M Kiriyama; T Ebata; T Aoba; Y Kaneoka; T Arai; Y Shimizu; M Nagino; Y Shimoyama; Y Fukami; H Miyake; E Sakamoto; D Takara; K Shirai; S Ohira; Y Tojima; M Hashimoto; A Akutagawa; R Yamaguchi; N Morofuji; T Kawahara; Y Asaba; S Mizuno; S Kawai; H Yamamoto; K Ikuta; H Matsubara; T Watanabe
• Keywords: Adult; Aged, 80 and over; Male; Kaplan-Meier Estimate; Middle Aged; Prognosis; Pancreaticoduodenectomy; 3. Good health; Cholangiocarcinoma; 03 medical and health sciences; Bile Ducts, Intrahepatic; 0302 clinical medicine; Bile Duct Neoplasms; Japan; Lymphatic Metastasis; Humans; Lymph Node Excision; Female; Lymph Nodes; Prospective Studies; Organ Sparing Treatments; Aged

Abstract Background The aim of the study was to investigate prognostic impact lymph node metastasis in cholangiocarcinoma using three different classifications. Methods Patients who underwent pancreaticoduodenectomy for distal 24 hospitals Japan between 2001 and 2010 were included. Survival calculated by means Kaplan–Meier method differences subgroups assessed with log rank test. Cox proportional hazards model used identify independent predictors survival. χ2 scores determine cut-off value number involved nodes, ratio (LNR) total count (TLNC) discriminating Results Some 370 patients median (range) TLNC 19 (3–59). Nodal occurred 157 (42·4 per cent); nodes LNR 2 (1–19) 0·11 (0·02–0·80) respectively. Four or more associated a significantly shorter survival (1·3 versus 2·2 years; P = 0·001), as at least 0·17 (1·4 2·3 0·002). Involvement along common hepatic artery, present 21 (13·4 cent), also (median 1·3 2·1 0·046). Multivariable analysis among node-positive identified an factor (risk 1·87; Conclusion strong predictor cholangiocarcinoma.