A comparative metabolomics study on dried and processed Rehmannia Radix

• DOI: 10.1002/bmc.5654
• Publication Date: 2023-04-18T06:21:00Z
• Authors: Tong Liu; Ning Zhou; Zhiyao Bai; Yumin Cao; Jinying Zhang; Yongxiang Wang; Xiaoke Zheng; Weisheng Feng
• Keywords: Rehmannia glutinosa; Radix (gastropod); Glucuronates; Catalpol

The efficacy of Rehmannia Radix changes after processing. However, the precise effect processing on properties is an intricate topic, as this cannot be explained by traditional methods. purpose study was to investigate how methods influence Radix, well in body function administering dried (RR) and processed (PR) using a metabolomics approach. In addition, principal component analysis orthogonal partial least-squares discriminant models were generated SIMCA-P 14.0 evaluate RR PR. Potential biomarkers identified, associated metabolic networks established clarify differences efficacies results showed that PR have cold hot properties, respectively. can exert hypolipidaemic regulating nicotinate nicotinamide metabolism. exerts tonic regulates body's reproductive through regulation alanine, aspartate glutamate metabolism, arachidonic acid, pentose glucuronate Ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry-based promising approach determine cold/hot Chinese medicine formulations.