Clinical and imaging characteristics of PFO‐related stroke with different amounts of right‐to‐left shunt

• DOI: 10.1002/brb3.1122
• Publication Date: 2018-10-12T04:09:18Z
• Authors: Dan He; Qian Li; Guangjin Xu; Zheng Hu; Xuefei Li; Yinping Guo; Shabei Xu; Wei Wang; Xiang Luo
• Keywords: Right-to-left shunt; Transcranial Doppler; Stroke; Paradoxical Embolism

Right-to-left shunt (RLS) induced by a patent foramen ovale (PFO) is associated with an increased risk of cryptogenic stroke (CS). However, little known about the relationship between amount RLS and pattern. In this study, we aimed to evaluate distinct clinical features PFO-related CS in different degrees resulting from PFO.This cohort study 222 patients admitted Tongji Hospital 1st May 2014 31st April 2017. All underwent contrast transcranial Doppler examination. And then, 121 (54.5%) were classified as non-RLS group, while 76 (34.2%) mild group 25 (11.3%) large according number micro-emboli signals. The groups compared respect their neuroimaging characteristics.In terms factors stroke, prevalence hypertension was lower (p = 0.002). Regarding infarct patterns patients, found that multiple cortical lesions more frequently observed (p<0.001) increasing DWI. Moreover, there rising trend proportion small (≤1 cm) < 0.01). increased, posterior circulation likely be influenced 0.05). addition, serum cholesterol concentration 0.003) 0.008). While mean platelet volume (MPV) significantly higher than 0.013).Patients larger show infarction circulation, frequency or lesions. results our indicate might clue stroke.