Increased EEG coherence in long‐distance and short‐distance connectivity in children with autism spectrum disorders

• DOI: 10.1002/brb3.1796
• Publication Date: 2020-08-28T07:22:25Z
• Authors: Jia Wang; Xiaomin Wang; Xuelai Wang; Huiying Zhang; Yong Zhou; Lei Chen; Yutong Li; Lijie Wu
• Keywords: Brain Mapping; Autism Spectrum Disorder; Brain; autism spectrum disorder; Neurosciences. Biological psychiatry. Neuropsychiatry; Electroencephalography; electroencephalogram; Temporal Lobe; coherence; 03 medical and health sciences; 0302 clinical medicine; Humans; Child; resting state; RC321-571; Original Research

Autism spectrum disorder (ASD) is a complex and prevalent neurodevelopmental characterized by deficits in social communication interaction as well repetitive behaviors. Alterations function connectivity are widely recognized recent electroencephalogram (EEG) studies. However, most studies have not reached consistent conclusions, which could be due to the developmental nature heterogeneity of ASD.Here, EEG coherence analysis was used cohort children with ASD (n = 13) matched typically developing controls (TD, n 15) examine functional characteristics long-distance short-distance electrode pairs. Subsequently, we explore association between strength symptom severity ASD.Compared TD group, individuals showed increased pairs right temporal-parietal region (delta, alpha, beta bands), left (all frequency occipital (theta, central-parietal prefrontal (only band). In analysis, group bilateral frontal region, temporal parietal frontal-occipital alpha bands. The such connections associated severity.Our study indicates that abnormal patterns neuroelectrophysiology may critical importance acknowledge underlying brain mechanism.