Optical coherence tomography angiography helps distinguish multiple sclerosis from AQP4‐IgG‐seropositive neuromyelitis optica spectrum disorder

• DOI: 10.1002/brb3.2125
• Publication Date: 2021-03-30T15:29:02Z
• Authors: Chunxin Liu; Hui Xiao; Xiayin Zhang; Yipeng Zhao; Rui Li; Xiaonan Zhong; Yuge Wang; Yaqing Shu; Yanyu Chang; Jingqi Wang; Caixia Li; Haotian Lin; Wei Qiu
• Keywords: Neuromyelitis Optica; Spectrum disorder

The aim was to characterize the optical coherence tomography (OCT) angiography measures in patients with multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) evaluate their disease discrimination capacity.Patients MS (n = 83) AQP4-IgG-seropositive NMOSD 91) or without a history of optic neuritis, together healthy controls 34), were imaged. main outcome peripapillary retinal nerve fiber layer (pRNFL) thickness, macular ganglion cell-inner plexiform (GC-IPL) vessel density (VD), perfusion (PD) superficial capillary plexus. Diagnostic accuracy assessed using area under receiver operating characteristics curve.Compared MS, those had significantly smaller average thickness pRNFL GC-IPL (80.0 [59.0; 95.8] μm versus 92.0 [80.2; 101] μm, p < .001; 68.0 [56.0; 81.0] 74.5 [64.2; .001) whole VD PD areas (15.6 [12.6; 17.0] mm-1 16.7 [14.8; 17.7] , 0.38 [0.31; 0.42] 0.40 [0.37; 0.43] .01). combination structural parameters (average GC-IPL) microvascular (temporal-inner quadrant VD, temporal-inner, nasal-inferior, nasal-outer PD) revealed have good diagnostic capability for discriminating between MS.OCT reveals different changes NMOSD. These combined might be promising biomarkers diagnosis.