Negative correlation between IL‐1β, IL‐12 and TNF‐γ, and cortisol levels in patients with panic disorder

• DOI: 10.1002/brb3.2624
• Publication Date: 2022-05-19T18:22:31Z
• Authors: Ana Belén Fernánd...; Francisco José Mo...; Cesar Augusto Gin...; Juan Carlos Ferná...
• Keywords: Proinflammatory cytokine; Hypothalamic–pituitary–adrenal axis

Chronic exposure to stress is a major risk factor in anxiety disorders (ADs) and can be accompanied by an altered microbiome-gut-brain axis compromised immune system. In recent years, the study of inflammatory processes AD has gained special attention. Continued causes reactivity hypothalamic-pituitary-adrenal (HPA) axis, alteration intestinal microbiota consequent release pro-inflammatory cytokines, affecting sensitivity similar behavior anxiety.The aim present was evaluate interrelationships between measures proinflammatory cytokines cortisol patients with panic disorder (PD).The main results correlation analysis revealed that levels interleukin (IL)-1β, IL-12, tumor necrosis gamma were negatively correlated scores (area under curve respect ground).These suggest response associated HPA PD may influence maintenance behavior.