Clinical value of video oculomotor evaluation in the differential diagnosis of multiple system atrophy and Parkinson's disease

• DOI: 10.1002/brb3.3510
• Publication Date: 2024-05-08T05:58:46Z
• Authors: Dongxiao Zhou; Qian Ma; Haiwei Huang; Xue Xu
• Keywords: Optokinetic reflex; Smooth pursuit

Abstract Background Multiple system atrophy (MSA) is a neurodegenerative disease that progresses rapidly and has poor prognosis. This study aimed to assess the value of video oculomotor evaluation (VOE) in differential diagnosis MSA Parkinson's (PD). Methods In total, 28 patients with MSA, 31 PD, 30 age‐ sex‐matched healthy controls (HC) were screened included this study. The consisted gaze‐holding test, smooth pursuit eye movement (SPEM), random saccade, optokinetic nystagmus (OKN). Results PD groups had more abnormalities decreased SPEM gain than HC group (64.29%, 35.48%, 10%, p < .001). was significantly lower at specific frequencies. Patients showed prolonged latencies all saccade directions compared those HC. However, two diseases no significant differences parameters. OKN gradually from ( .05). Compared group, further test 30°/s (Left, = .010; Right .016). Receiver operating characteristic curves combination parameters age course could aid sensitivity 89.29% specificity 70.97%. Conclusions clinical data may PD. Furthermore, VOE vital identification diseases.