Musashi2 as a novel predictive biomarker for liver metastasis and poor prognosis in colorectal cancer

• DOI: 10.1002/cam4.624
• Publication Date: 2016-01-18T05:34:38Z
• Authors: Zhen Zong; Taicheng Zhou; Liangjun Rao; Zhipeng Jiang; Yingru Li; Zehui Hou; Bin Yang; Fanghai Han; Shuang Chen
• Keywords: Microsatellite Instability; Tissue microarray

Abstract Aberrant expression of musashi2 ( MSI ‐2) has been detected in several malignancies. However, its role the progression colorectal cancer CRC ) remains unknown. Our study was designed to investigate and prognostic significance ‐2 protein patients with cancer. The 164 patients’ control specimens by tissue microarray technique immunohistochemical staining. correlations between clinicopathological variables including overall survival were analyzed. value liver metastasis is evaluated logistic regression receiver operating characteristic ROC analysis. highly expressed 32.9% (54/164) Overexpression associated depth invasion, lymph node metastasis, distant Tumor Node Metastasis (TNM) clinical stage, Carcinoembryonicantigen (CEA) level P = 0.040, 0.014, <0.001, 0.003, 0.002, respectively). In Cox multivariate test, overexpression, found be independent factors 0.027, 0.010, 0.001, Further suggested that TNM stage high related patients. Conclusively, our indicates overexpression an unfavorable prognosis may a potential biomarker for