Plasma xanthine oxidase, superoxide dismutase and glutathione peroxidase activities and uric acid levels in severe and mild pre‐eclampsia

• DOI: 10.1002/cbf.1090
• Publication Date: 2004-06-21T10:01:22Z
• Authors: Abdulkadir Yildirim; Konca Altinkaynak; Hulya Aksoy; Y. Nuri Sahin; Fatih Akcay
• Keywords: Adult; 0301 basic medicine; Glutathione Peroxidase; Xanthine Oxidase; Superoxide Dismutase; Pregnancy Trimester, Third; Blood Pressure; Severity of Illness Index; Uric Acid; Oxidative Stress; Young Adult; 03 medical and health sciences; Pre-Eclampsia; Pregnancy; Humans; Female; Reactive Oxygen Species

Abstract The aim of the present study was to measure plasma uric acid (UA) levels and superoxide dismutase (SOD), glutathione peroxidase (GSH‐Px) xanthine oxidase (XO) activities evaluate relationship between these parameters severity pre‐eclampsia. Twenty‐five pre‐eclamptic, 15 healthy pregnant non‐pregnant women were enrolled in this study. Increased mean XO activity found be higher both pre‐eclampsia groups than group. Plasma UA highest severe group among groups. SOD GSH‐Px significantly lower ( p < 0.005 0.001, respectively). decreased may contribute pathophysiological mechanisms increased serve a protective role responding radicals arising from or other sources Copyright © 2004 John Wiley & Sons, Ltd.