Glutathione S‐transferase gene polymorphisms in Turkish patients with diabetes mellitus

• DOI: 10.1002/cbf.1339
• Publication Date: 2006-08-23T07:13:22Z
• Authors: Serap Yalin; Rezan Hatungil; Lulufer Tamer; Nurcan Aras Ates; Nil Dogruer; Hatice Yildirim; Sevim Karakas; Ugur Atik
• Keywords: GSTP1; Turkish population; Glutathione S-transferase

Abstract Glutathione S ‐transferases (GSTs) are enzymes involved in the metabolism of many disease‐causing electrophilic substrates and protect cells against oxidative stress. In present study, we investigated GSTM1 , GSTT1 GSTP1 gene polymorphisms diabetic patients healthy individuals searched whether GST genes associated with diabetes mellitus (DM) Turkish population. The study population consisted 98 unrelated DM. Genotyping was performed using real time polymerase chain reaction a Light Cycler instrument. Patients had higher frequency null genotype than control group (Odds ratios, OR = 3.7; 95% confidence intervals, CI 2.05–6.70). However, there no significant difference frequencies between group. combined analysis these three genotypes showed further DM risk increase (OR 5.7, 1.51–31.07). This is first to determine association polymorphism These results show that may play role aetiopathogeneses be useful marker prediction susceptibility Copyright © 2006 John Wiley & Sons, Ltd.