The effects of rosiglitazone on oxidative stress and lipid profile in left ventricular muscles of diabetic rats

• DOI: 10.1002/cbf.1469
• Publication Date: 2008-03-17T18:49:39Z
• Authors: Servet Kavak; Lokman Ayaz; Mustafa Emre; Tamer Inal; Lülüfer Tamer; Ismail Günay
• Keywords: 3-nitrotyrosine; Blood Glucose; Glycated Hemoglobin; Male; 0303 health sciences; Heart Ventricles; Body Weight; Lipid Metabolism; Streptozocin; Diabetes Mellitus, Experimental; Rats; 3. Good health; Rosiglitazone; Oxidative Stress; 03 medical and health sciences; Diabetes mellitus; Oxidative stress; Malondialdehyde; Animals; Tyrosine; Thiazolidinediones; Rats, Wistar

AbstractWe investigated the effect of rosiglitazone (RSG), a high‐affinity ligand for the peroxisome proliferator‐activated receptor gamma which mediates insulin‐sensitizing actions, on the lipid profile and oxidative status in streptozotocin (STZ)‐induced Type 2 diabetes mellitus (DM) rats. Wistar albino male rats were randomly divided into an untreated control group (C), a C + RSG group which was treated with RSG (4 mg kg−1) two times a day by gavage, a diabetic group (D) that was treated with a single intraperitoneal injection of STZ (45 mgkg−1), D + RSG group which were treated with RSG two times a day by gavage, respectively. Lipid profiles, HbA1cand blood glucose levels in the circulation and malondialdehyde (MDA) and 3‐nitrotyrosine (3‐NT) levels in left ventricular muscle were measured. Treatment of D rats with RSG resulted in a time‐dependent decrease in blood glucose. We found that the lipid profile and HbA1clevels in D + RSG group reached the C rat values at the end of the treatment period. There was a statistically significant difference between the C + RSG and C groups in 3‐NT levels. In group D, 3‐NT and MDA levels were found to be increased when compared with C, C + RSG and D + RSG groups. In the D + RSG group, MDA levels were found to be decreased when compared with C and C + RSG. Our study suggests that the treatment of D rats with RSG for 8 weeks may decrease the oxidative/nitrosative stress in left ventricular tissue of rats. Thus in diabetes‐related vascular diseases, RSG treatment may be cardioprotective. Copyright © 2008 John Wiley & Sons, Ltd.