A Novel Mycolactone from a Clinical Isolate of Mycobacterium ulcerans Provides Evidence for Additional Toxin Heterogeneity as a Result of Specific Changes in the Modular Polyketide Synthase

• DOI: 10.1002/cbic.200400339
• Publication Date: 2005-03-07T12:18:12Z
• Authors: Hui Hong; Jonathan B. Spencer; Jessica L. Porter; Peter F. Leadlay; Tim Stinear
• Keywords: Mycobacterium ulcerans; Polyketide synthase; Buruli ulcer

New analogues of the toxin mycolactone have been identified in a pathogenic Chinese strain Mycobacterium ulcerans. They possess an extra methyl group at C2′ (shown red) compared to A as result recruitment single catalytic domain altered specificity polyketide synthase.