Functionalized Fluorescent Organic Nanoparticles Based AIE Enabling Effectively Targeting Cancer Cell Imaging

• DOI: 10.1002/cbic.202300391
• Publication Date: 2023-09-18T02:44:12Z
• Authors: Jing Zhang; Jiaqi Liu; Chengyan Niu; Qiulan Wu; Jingjing Tan; Ning Jing; Ying Wen
• Keywords: Tetraphenylethylene; Biocompatibility; Stokes shift; Supramolecular chirality

Abstract We report a fluorescent dye TM by incorporating the tetraphenylethylene (TPE) and cholesterol components into perylene bisimides (PBI) derivative. Fluorescence emission spectrum shows that has stable red aggregation‐induced (AIE) characteristics. The incorporation of triggers to show induced chirality through supramolecular self‐assembly. cRGD‐functionalized nanoparticles were prepared encapsulating dyes with amphiphilic polymer matrix. functionalized organic exhibit excellent biocompatibility, large Stokes’ shift good photostability, which make them effective probes for targeting cancer cells high fluorescence contrast.