The effect of glutamate on ghrelin release in mice

• DOI: 10.1002/cbin.10728
• Publication Date: 2017-01-09T10:18:57Z
• Authors: Rakhi Chacrabati; Zhi Gong; Chika Ikenoya; Daisuke Kondo; Jeffrey M. Zigman; Takafumi Sakai; Ichiro Sakata
• Keywords: Male; Mice, Inbred C57BL; 0301 basic medicine; Eating; Mice; 03 medical and health sciences; Dose-Response Relationship, Drug; Gastric Mucosa; Animals; Glutamic Acid; Cells, Cultured; Ghrelin

Ghrelin is abundantly produced in the stomach. Here, we found that glutamate decreased ghrelin expression and release ghrelin-producing cells, levels of food intake plasma acyl-ghrelin mice. Treatment with siRNA G protein-coupled receptor, family C, group 5, member B (GPRC5B) cell lines completely blocked effect glutamate-induced suppression. In addition, inhibited via extracellular signal-regulated kinase (ERK) activity pathway, stimulated CREB2 mRNA lines. These results suggest inhibits ERK-CREB2 pathway. GPRC5B-ERK-CREB2 pathway involved inhibition secretion cells.