Gö6983 attenuates breast cancer‐induced osteolysis by the apoptotic pathway

• DOI: 10.1002/cbin.11281
• Publication Date: 2019-12-09T05:52:25Z
• Authors: Zhiwei Luan; Jia Li; Xing Huang; Wenyu Feng; Shiting Ma; Fengyang Song; Zhengyuan Wu; Xiaohan Zhang; Linfeng Wei; Zhenyi Yang; Jun Yao
• Keywords: Osteolysis

Abstract Bone metastasis caused by breast cancer leads to significant complications in treatment, and the resulting osteolysis considerably affects patients’ overall survival quality of life. Gö6983 is a broad spectrum protein kinase C inhibitor. In this study, based on our finding that inhibits osteolysis, we applied MDA‐MB‐231 cancer‐induced mouse bone model. And found has strong inhibitory effect tumorigenic model promoting mitochondrial apoptosis pathway. Our therefore, demonstrates potential osteoclast activation provides mechanistic insight may prove useful for designing future treatments.