Gö6983 attenuates breast cancer‐induced osteolysis by the apoptotic pathway

0301 basic medicine 0303 health sciences Indoles Macrophages Mice, Nude Osteoclasts Apoptosis Bone Neoplasms Breast Neoplasms Cell Differentiation Osteolysis Mitochondria 3. Good health Maleimides Mice, Inbred C57BL Mice 03 medical and health sciences Cell Line, Tumor Animals Protein Kinase Inhibitors
DOI: 10.1002/cbin.11281 Publication Date: 2019-12-09T05:52:25Z
ABSTRACT
AbstractBone metastasis caused by breast cancer leads to significant complications in treatment, and the resulting osteolysis considerably affects patients’ overall survival and quality of life. Gö6983 is a broad spectrum protein kinase C inhibitor. In this study, based on our finding that the Gö6983 inhibits osteolysis, we applied Gö6983 to the MDA‐MB‐231 breast cancer‐induced mouse bone metastasis model. And we found that Gö6983 has a strong inhibitory effect on the tumorigenic model of breast cancer by promoting the mitochondrial apoptosis pathway. Our study, therefore, demonstrates that Gö6983 has a potential inhibitory effect on breast cancer‐induced osteoclast activation and provides mechanistic insight that may prove useful for designing future treatments.
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