Gö6983 attenuates breast cancer‐induced osteolysis by the apoptotic pathway

• DOI: 10.1002/cbin.11281
• Publication Date: 2019-12-09T05:52:25Z
• Authors: Zhiwei Luan; Jia Li; Xing Huang; Wenyu Feng; Shiting Ma; Fengyang Song; Zhengyuan Wu; Xiaohan Zhang; Linfeng Wei; Zhenyi Yang; Jun Yao
• Keywords: 0301 basic medicine; 0303 health sciences; Indoles; Macrophages; Mice, Nude; Osteoclasts; Apoptosis; Bone Neoplasms; Breast Neoplasms; Cell Differentiation; Osteolysis; Mitochondria; 3. Good health; Maleimides; Mice, Inbred C57BL; Mice; 03 medical and health sciences; Cell Line, Tumor; Animals; Protein Kinase Inhibitors

AbstractBone metastasis caused by breast cancer leads to significant complications in treatment, and the resulting osteolysis considerably affects patients’ overall survival and quality of life. Gö6983 is a broad spectrum protein kinase C inhibitor. In this study, based on our finding that the Gö6983 inhibits osteolysis, we applied Gö6983 to the MDA‐MB‐231 breast cancer‐induced mouse bone metastasis model. And we found that Gö6983 has a strong inhibitory effect on the tumorigenic model of breast cancer by promoting the mitochondrial apoptosis pathway. Our study, therefore, demonstrates that Gö6983 has a potential inhibitory effect on breast cancer‐induced osteoclast activation and provides mechanistic insight that may prove useful for designing future treatments.