ARID3A promotes the chemosensitivity of colon cancer by inhibiting AKR1C3

• DOI: 10.1002/cbin.11789
• Publication Date: 2022-03-08T06:41:59Z
• Authors: Yafei Li; Jing Tang; Jing Li; Yaru Du; Fuqiang Bai; Lirui Yang; Xiaobo Li; Xiaoming Jin; Tianzhen Wang
• Keywords: DNA-Binding Proteins; 03 medical and health sciences; 0302 clinical medicine; Drug Resistance, Neoplasm; Cell Line, Tumor; Colonic Neoplasms; Aldo-Keto Reductase Family 1 Member C3; Humans; Fluorouracil; Transcription Factors; Up-Regulation; 3. Good health

ARID3A is upregulated in colorectal cancer and can promote the proliferation metastasis of cells. However, patients with higher level have a better prognosis. This study aimed to uncover mechanism by which benefits prognosis colon cancer. Our results indicated that upregulation enhanced chemosensitivity cells 5-fluorouracil (5-FU), whereas downregulation inhibited 5-FU. Through database analysis, we found AKR1C3, drug resistance-related gene, was target ARID3A. Moreover, AKR1C3 downregulated tissues compared normal tissues. Next, assessed interaction between ARID3A, transcription leading We also verified ratio had suggested promoted inhibiting The good marker predict patients.