TCF12 induces ferroptosis by suppressing OTUB1‐mediated SLC7A11 deubiquitination to promote cisplatin sensitivity in oral squamous cell carcinoma

• DOI: 10.1002/cbin.12211
• Publication Date: 2024-07-01T05:30:05Z
• Authors: Yanchun Liu; Qin Bai; Nan Pang; Jun Xue
• Keywords: Carcinoma Cell

Chemotherapy resistance is a major obstacle to effective cancer treatment, and promotion of ferroptosis can suppress cisplatin in tumor cells. TCF12 plays suppressive role oral squamous cell carcinoma (OSCC), but whether it participates the regulation by modulating remains unclear. Here, we found that expression was decreased OSCC cells compared with normal cells, reduced (DDP)-resistant parental Moreover, overexpression sensitized DDP-resistant DDP promoting ferroptosis. Intriguingly, silencing reversed effect activator RSL3 on sensitivity, overexpressing antagonized inhibitor liproxstatin-1 resistance. Mechanically, promoted ubiquitination SLC7A11 protein stability through transcriptional repression OTUB1, thereby facilitating Consistently, neutralized sensitivity. Additionally, upregulation hindered growth mouse xenografts enhanced sensitivity inducing In conclusion, ferroptosis, which achieved via OTUB1.