Enhanced Ceftriaxone Determination using a Glassy Carbon Electrode Modified with a Cr‐Based Metal‐Organic Framework Film Stabilized by β‐Cyclodextrin Polymer

• DOI: 10.1002/celc.202300603
• Publication Date: 2024-03-21T12:24:49Z
• Authors: Honorine Hortense...; Liliane Medonbou ...; Sherman Lesly Zam...; Tobie Matemb Ma Ntep; Serge Foukmeniok ...; Christoph Janiak; Rousseau Djouaka; Ignas Kenfack Tonle
• Keywords: Amperometry; Electrochemical gas sensor; Differential pulse voltammetry; Carbon paste electrode

Abstract A selective amperometric sensor was developed to detect the antibiotic ceftriaxone (CEF) using a composite film of poly(β‐cyclodextrin) and metal‐organic framework (MOF). The obtained by electro‐polymerizing β‐cyclodextrin (β‐CD) onto glassy carbon electrode (GCE) previously coated with MIL‐101(Cr) MOF film. This design prevents particles’ loss during extended use. structurally characterized scanning electron microscopy, X‐ray diffraction, N 2 adsorption‐desorption isotherms (BET method) FTIR spectroscopy. Electrochemical impedance spectroscopy cyclic voltammetry were used assess GCE/MIL‐101(Cr)‐pβ‐CD sensor, revealing reduced charge transfer resistance enhanced sensitivity CEF. Differential pulse then employed for CEF determination. Under optimized conditions, exhibited high sensitivity, broad linear working range 0.5 6 μM (R =0.991), low detection limit 0.34±0.02 (0.19±0.01 mg L −1 ). selectivity evaluated in presence potential interferences such as organic acids, antibiotics selected ions expected affect signal. In an application quantify pharmaceutical formulation, displayed impressive recovery rate 98.3 % compared results high‐performance liquid chromatography.