ChemInform Abstract: Synthesis and Cytotoxicity Evaluation of Biaryl‐Based Chalcones and Their Potential in TNFα‐Induced Nuclear Factor‐ϰB Activation Inhibition.

• DOI: 10.1002/chin.201235083
• Publication Date: 2012-08-03T18:52:20Z
• Authors: Yinglin Zuo; Yi Yu; Shuni Wang; Weiyan Shao; Binhua Zhou; Li Lin; Zhuoyu Luo; Ruogo Huang; Jun Du; Xianzhang Bu
• Keywords: 0301 basic medicine; 0303 health sciences; Molecular Structure; Cell Survival; Tumor Necrosis Factor-alpha; NF-kappa B; Antineoplastic Agents; Protein Transport; Structure-Activity Relationship; 03 medical and health sciences; Chalcones; Cell Line, Tumor; Neoplasms; Humans; Cell Proliferation

Abstract A variety of biaryl‐based chalcones are designed, synthesized and evaluated for their inhibitory activities against five cancer cell lines.