ChemInform Abstract: Condensation Reactions of Guanidines with Bis‐electrophiles: Formation of Highly Nitrogenous Heterocycles.

• DOI: 10.1002/chin.201402165
• Publication Date: 2013-12-20T17:59:55Z
• Authors: David M. Arnold; Matthew G. LaPorte; Shelby M. Anderson; Peter Wipf
• Keywords: 01 natural sciences; 0104 chemical sciences

2-Amino-1,4-dihydropyrimidines were reacted with bis-electrophiles to produce novel fused bi-pyrimidine, pyrimido-aminotriazine, and pyrimido-sulfonamide scaffolds. In addition, a quinazoline library was constructed using a guanidine Atwal-Biginelli reaction with 1-(quinazolin-2-yl)guanidines. The product heterocycles have novel constitutions with high nitrogen atom counts and represent valuable additions to screening libraries for the discovery of new modulators of biological targets.