ChemInform Abstract: Copper‐Catalyzed Trifluoromethylation‐Initiated Radical Oxidative Annulation Toward Oxindoles.

• DOI: 10.1002/chin.201439123
• Publication Date: 2014-09-11T11:43:20Z
• Authors: Qingquan Lu; Chao Liu; Pan Peng; Zhiliang Liu; Lijun Fu; Jinguo Huang; Aiwen Lei
• Keywords: Annulation; Trifluoromethylation

A copper-catalyzed radical oxidative trifluoromethylation and arylation of electron-withdrawing alkenes has been developed, in which economical sodium trifluoromethanesulfinate is used as the CF3 source. A preliminary kinetic investigation indicated that the generation of CF3 radicals under the mild conditions might be a facile process.