ChemInform Abstract: Metal Free Formation of Various 3‐Iodo‐1H‐pyrrolo[3′,2′:4,5]imidazo‐[1,2‐a]pyridines and [1,2‐b]Pyridazines and Their Further Functionalization.

• DOI: 10.1002/chin.201546072
• Publication Date: 2015-10-27T09:58:13Z
• Authors: Z. Tber; M.‐a. Hiebel; A. El Hakmaoui; M. Akssira; G. Guillaumet; S. Berteina‐Raboin
• Keywords: Pyridazines; Molecular Structure; Cyclization; Metals; Pyridines; 01 natural sciences; Catalysis; Palladium; Iodine; 0104 chemical sciences

3-iodo-1H-pyrrolo[3',2':4,5]imidazo-[1,2-a]pyridines and [1,2-b]pyridazines were prepared following Groebke-Blackburn-Bienaymé MCR combined with I2-promoted electrophilic cyclization. The flexibility of the method enables the introduction of diversity in the 2, 5, 6, and 7 positions on the resulting scaffold using commercially available starting materials. Furthermore, subsequent palladium-catalyzed reactions were successfully achieved using our iodinated derivatives.