ChemInform Abstract: Synthesis of Trifluoromethylated Azetidines, Aminopropanes, 1,3‐Oxazinanes, and 1,3‐Oxazinan‐2‐ones Starting from 4‐Trifluoromethyl‐β‐lactam Building Blocks.

• DOI: 10.1002/chin.201636054
• Publication Date: 2016-08-18T08:19:01Z
• Authors: Hang Dao Thi; Lena Decuyper; Karen Mollet; Sara Kenis; Norbert De Kimpe; Tuyen Van Nguyen; Matthias D'hooghe
• Keywords: 01 natural sciences; 0104 chemical sciences

This paper reports on the preparation of 4-(trifluoromethyl)azetidin-2-ones and their synthetic potential as eligible new building blocks for the construction of CF3-containing azetidines, diaminopropanes, aminopropanol derivatives, 1,3-oxazinanes, and 1,3-oxazinan-2-ones. This β-lactam building block approach provides a convenient new entry into trifluoromethylated scaffolds as useful synthetic intermediates en route to a variety of CF3-functionalized target structures.