ChemInform Abstract: Preparation of 2,3,3‐Triarylacrylic Acid Esters Using Suzuki—Miyaura Coupling Reactions.

• DOI: 10.1002/chin.201636063
• Publication Date: 2016-08-18T08:19:01Z
• Authors: Sebastien Cardinal; Normand Voyer
• Keywords: 01 natural sciences; 0104 chemical sciences

We report here a new strategy to produce 2,3,3-triarylacrylic acid esters, a class of 1,2,2-triarylethene compounds with an α,β-unsaturated ester functionality. Our approach requires the preparation of a gem-dibromoalkene precursor from an α-keto ester, followed by the installation of two aryl groups by Suzuki–Miyaura coupling reactions on the two C–Br bonds. Many 2,3,3-triarylacrylic acid esters with one, two, or three different aryl groups were obtained with complete regio- and stereocontrol in most cases.