Pd(II)‐Catalyzed Phosphorylation of Enamido C(sp2)–H Bonds: A General Route to β‐Amido‐vinylphosphonates

• DOI: 10.1002/cjoc.201800262
• Publication Date: 2018-06-14T09:57:55Z
• Authors: Baokun Qiao; Hao‐Qiang Cao; Yin‐Jun Huang; Yue Zhang; Jing Nie; Fa‐Guang Zhang; Jun‐An Ma
• Keywords: 01 natural sciences; 0104 chemical sciences

Abstract Organophosphorus compounds are essential structures in modern pharmaceutical, agrochemical, and material sciences. The development of new efficient methods for the synthesis C–P bonds has been an important focus research. We herein report a Pd‐catalyzed enamido C(sp 2 )–H phosphorylation direct construction under simple convenient conditions without need additional ligands or directing groups. present reaction can tolerate wide range functional groups, furnish variety products including tetrasubstituted‐vinyl β‐aminophosphonates that otherwise difficult to access. This protocol was also exemplified into late‐stage modification bioactive natural suitable large‐scale synthesis.