Synthesis of Phenanthridine and Quinoxaline Derivatives viaCopper‐Catalyzed Radical Cyanoalkylation of Cyclobutanone Oxime Esters and Vinyl Azides

• DOI: 10.1002/cjoc.202100050
• Publication Date: 2021-04-02T06:59:55Z
• Authors: Qi Liang; Long Lin; Guodong Li; Xianqiang Kong; Bo Xu
• Keywords: 01 natural sciences; 0104 chemical sciences

Main observation and conclusionA copper‐catalyzed radical cyclization of cyclobutanone oxime esters and vinyl azide is described. This method provides facile access to cyanoalkyl‐substituted phenanthridines and quinoxalines with excellent isolated yields. Moreover, these reactions proceed under mild conditions with a board substrate scope and excellent functional group tolerance.