Adenosine and 2′‐Deoxyadenosine Modified with Boron Cluster Pharmacophores as New Classes of Human Blood Platelet Function Modulators

• DOI: 10.1002/cmdc.201000075
• Publication Date: 2010-04-01T18:05:35Z
• Authors: Katarzyna Bednarska; Agnieszka B. Olej...; Błażej A. Wojtczak; Zofia Sułowska; Zbigniew J. Leśni...
• Keywords: Deoxyadenosine; Human blood

Novel types of adenosine and 2'-deoxyadenosine derivatives containing boron clusters at positions C2', N6, or C8 were synthesized. The effect these modified compounds on platelet function was studied. Modification the C2' position with a para-carborane cluster (C(2)B(10)H(11)) results in efficient inhibition function, including aggregation, protein secretion, P-selectin expression induced by thrombin ADP. These preliminary findings new chemistry proposed form basis for development class analogues that modulate human blood activities.