A Comparison of Linear and Cyclic Peptoid Oligomers as Potent Antimicrobial Agents

• DOI: 10.1002/cmdc.201100358
• Publication Date: 2011-09-27T22:40:28Z
• Authors: Mia Lace Huang; Sung Bin Y. Shin; Meredith A. Benson; Victor J. Torres; Kent Kirshenbaum
• Keywords: Peptoid

Abstract We investigated the antimicrobial activities of N‐substituted glycine “peptoid” oligomers incorporating cationic and hydrophobic side chains. Head‐to‐tail macrocyclization was employed to enhance activity. Both linear cyclic peptoids, ranging from six ten residues, demonstrate potent activity against Gram‐positive Gram‐negative bacteria. These peptoids do not cause significant lysis human erythrocytes, indicating selective Conformational ordering established upon is generally associated with an enhanced capacity inhibit bacterial cell growth. Moreover, increased surface area also plays a role in improving potency peptoid exerting clinical strains S. aureus while deterring emergence resistance.