Study of the Anticancer Properties of Tin(IV) Carboxylate Complexes on a Panel of Human Tumor Cell Lines

P-glycoprotein Efflux Viability assay K562 cells
DOI: 10.1002/cmdc.201100432 Publication Date: 2011-12-13T13:28:59Z
ABSTRACT
Abstract A group of organotin(IV) complexes were prepared: [SnCy 3 (DMNI)] ( 1 ), (BZDO)] 2 (DMFU)] and [SnPh (BZDO) ] 4 for which DMNIH=2,6‐dimethoxynicotinic acid, BZDOH=1,4‐benzodioxane‐6‐carboxylic DMFUH=2,5‐dimethyl‐3‐furoic acid. The cytotoxic activities compounds – tested against pancreatic carcinoma (PANC‐1), erythroleukemia (K562), two glioblastoma multiform (U87 LN‐229) human cell lines; they show very high antiproliferative activity, with IC 50 values in the 150–700 n M range after incubation 72 h. Distribution cellular DNA upon treatment revealed that whereas induce apoptosis most lines, compound does not affect viability any line tested, indicating a possible difference mechanism. Studies daunomycin‐resistant K562/R expressing P‐glycoprotein (Pgp) showed are substrates this protein efflux pump, these do acquisition multidrug resistance, is associated overexpression Pgp.
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