A Combined Bioinformatics and Chemoinformatics Approach for Developing Asymmetric Bivalent AMPA Receptor Positive Allosteric Modulators as Neuroprotective Agents

• DOI: 10.1002/cmdc.201200554
• Publication Date: 2012-12-22T03:13:08Z
• Authors: Haijun Chen; Cheng Z. Wang; Chunyong Ding; Christopher Wild; Bryan Copits; Geoffrey T. Swanson; Kenneth M. Johnson; Jia Zhou
• Keywords: Cheminformatics; Allosteric modulator

PAMs new in town! An effective, combined bioinformatics and chemoinformatics approach was applied to the design of novel asymmetric bivalent α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor positive allosteric modulators (PAMs) with marked potency vitro efficacy vivo for preventing neuroapoptosis. The chemotype could provide pharmacological probes potential therapeutic agents glutamatergic hypofunction its related neurological psychiatric disorders. As a service our authors readers, this journal provides supporting information supplied by authors. Such materials are peer reviewed may be re-organized online delivery, but not copy-edited or typeset. Technical support issues arising from (other than missing files) should addressed Please note: publisher is responsible content functionality any Any queries content) directed corresponding author article.