Employing Photoredox Catalysis for DNA‐Encoded Chemistry: Decarboxylative Alkylation of α‐Amino Acids

• DOI: 10.1002/cmdc.201800492
• Publication Date: 2018-08-01T12:09:49Z
• Authors: Dominik K. Kölmel; Richard P. Loach; Thomas Knauber; Mark E. Flanagan
• Keywords: Photoredox catalysis

A new procedure for the photoredox-mediated conjugate addition of radicals that can be conveniently generated from α-amino acids to DNA-tagged Michael acceptors and styrenes is presented. This C(sp3 )-C(sp3 ) coupling tolerates a broad array structurally diverse radical precursors, including all 20 proteinogenic amino acids. Importantly, this reaction proceeds under mild conditions in DNA-compatible aqueous media. Furthermore, presented are compatible with DNA, making platform well suited construction DNA-encoded libraries. The scope limitations chemistry discussed herein along proposals how methodology might used construct