Sulfated and Oxygenated Imidazoline Derivatives: Synthesis, Antioxidant Activity and Light‐Mediated Antibacterial Activity

• DOI: 10.1002/cmdc.202000048
• Publication Date: 2020-03-07T02:58:25Z
• Authors: Martín S. Faillace; Ana P. Silva; Antonio L. Alves ...; Luciana Muratori ...; Humberto M. Barreto; Walter J. Peláez
• Keywords: S. AUREUS; Staphylococcus aureus; Light; MICROWAVE CHEMISTRY; Microbial Sensitivity Tests; 01 natural sciences; Antioxidants; Structure-Activity Relationship; ANTIOXIDANTS; Picrates; ANTIBIOTIC RESISTANCE; https://purl.org/becyt/ford/1.4; Escherichia coli; Benzothiazoles; https://purl.org/becyt/ford/1; Imidazolines; Dose-Response Relationship, Drug; Molecular Structure; Biphenyl Compounds; Anti-Bacterial Agents; 0104 chemical sciences; 3. Good health; Sulfonic Acids; IMIDAZOLINE

AbstractImidazoline derivatives with different exocyclic substituents were simply prepared from common starting materials. The procedures were carried out in an eco‐friendly manner. The antioxidant activity of these derivatives was explored by different experimental assays, such as ABTS.+ and DPPH. scavenging assay, as well as reducing power assay. The structural differences are discussed in terms of the results. Sulfur analogs showed higher antioxidant activity than their oxygenated counterparts. The same tendency was observed in microbiological studies, in which the same imidazoline compounds were assayed for light‐mediated activity against of Staphylococcus aureus and Escherichia coli strains. A light‐enhanced activity was observed for almost all the sulfated imidazolines after exposure to UV‐A (400‐320 nm) light.